Alexander Fleming discovered Penicillin in 1928. He received the Nobel prize for his discovery in 1945.
A Facebook friend shared his Nobel lecture. Particularly, the following quote:
“The time may come when penicillin can be bought by anyone in the shops. Then there is the danger that the ignorant man may easily underdose himself and by exposing his microbes to non-lethal quantities of the drug make them resistant. Here is a hypothetical illustration. Mr. X. has a sore throat. He buys some penicillin and gives himself, not enough to kill the streptococci but enough to educate them to resist penicillin. He then infects his wife. Mrs. X gets pneumonia and is treated with penicillin. As the streptococci are now resistant to penicillin the treatment fails. Mrs. X dies. Who is primarily responsible for Mrs. X’s death? Why Mr. X whose negligent use of penicillin changed the nature of the microbe. Moral: If you use penicillin, use enough.“
Fleming thus foresaw the dangers of emerging antibiotic resistance. Too bad the world failed to listen. Now, a growing number of people die from once treatable (e.g., post-operative) infections because the evolution of bacteria outpaced our ability to develop new antibiotics.